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Chemdea |
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Y-27632 – ROCK Inhibitor |
Catalog # CD0141 |
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Price: 1 mg - $35; 5 mg - $55; 10 mg - $89; 25
mg - $195; 50 mg - $350; 100 mg - $650; 250 mg - $1450, 1 g - inquire Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx |
Availability: In stock |
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(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide Dihydrochloride
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS.
Purity: 99% by HPLC. Optically and isomerically
pure. CAS# 146986-50-7. Solubility: water (100
mg/mL). Molecular Formula: C14H21N3O·2HCl·H2O. Molecular Weight: 338.3.
A highly potent, cell-permeable, reversible, and selective
inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160ROCK (ROCK-I). Also inhibits
ROCK-II with almost equal potency. Inhibition is achieved by competing with
ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity
for PKCε than p160ROCK.
Does not affect the activity of p21-activated protein kinase
(PAK) even at high concentrations (~100 µM). Also acts as a potent inhibitor
of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC50
= 700 nM for phenylephrine-induced
contractions in aortic strips). Prevents apoptosis and enhances the survival
and cloning efficiency of dissociated hES
cells without affecting their pluripotency.
Reference: 1.
Watanabe,
K. et al. Nature Biotech. 2007,
25,
681; 2. Chitaley, K. et al. Nat.
Med. 2001, 7,
119; 3. Davies, S. P. et al. Biochem. J. 2000, 351,
95; 4. Narumiya, S. et al. Methods Enzymol.
2000, 325, 273;
5. Hirose, M. et al. J. Cell
Biol. 1998, 141,
1625; 6. Maekawa, M. et al. Science 1999, 285, 895;
7. Uehata, M. et al. Nature 1997, 389, 990. |
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SAME PRODUCT AS: |
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Cat. No. ALX-270-333 |
Cat. No. 10005583 |
Cat. No. ALX-270-333 |
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Cat. No. 688000 |
Cat. No. 1254 |
Cat. No. Y0503 |
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CHEMDEA; |