Chemdea

 

Home

Our Ligands

Order

Quote Larger Quantity

  

Y-27632 ROCK Inhibitor

Catalog # CD0141

Price:  1 mg - $35; 5 mg - $55; 10 mg - $89; 25 mg - $195; 50 mg - $350; 100 mg - $650; 250 mg - $1450, 1 g - inquire

Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx

Availability:  In stock

 

 

(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide Dihydrochloride

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. Optically and isomerically pure. CAS# 146986-50-7. Solubility: water (100 mg/mL). Molecular Formula: C14H21N3O2HClH2O. Molecular Weight: 338.3.

 

 

 

 

A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. Inhibition is achieved by competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at high concentrations (~100 M). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC50 = 700 nM for phenylephrine-induced contractions in aortic strips). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.

 

Reference: 1. Watanabe, K. et al. Nature Biotech. 2007, 25, 681; 2. Chitaley, K. et al. Nat. Med. 2001, 7, 119; 3. Davies, S. P. et al. Biochem. J. 2000, 351, 95; 4. Narumiya, S. et al. Methods Enzymol. 2000, 325, 273; 5. Hirose, M. et al. J. Cell Biol. 1998, 141, 1625; 6. Maekawa, M. et al. Science 1999, 285, 895; 7. Uehata, M. et al. Nature 1997, 389, 990.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. ALX-270-333

 

Cayman Chemical

Cat. No. 10005583

 

Enzo Life Sciences 

Cat. No. ALX-270-333

EMD

Cat. No. 688000

Tocris   

Cat. No. 1254

Sigma

Cat. No. Y0503

 

 

Caution Not fully tested. For research use only. Not for human use.

CHEMDEA; 38 E Ridgewood Ave.; Suite 240; Ridgewood, NJ 07450; USA

tel: (201) 690-4091; fax: (201) 690-4092; e-mail: contact@chemdea.com;  web: http://www.chemdea.com/