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Fasudil (HA 1077) Dihydrochloride ROCK Inhibitor

Catalog # CD0160

Price:  250 mg - $42; 500 mg - $69; 1 g - $129; 2 g - $234; 5 g - $545

Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx

Availability:  In stock

 

 

5-Isoquinolinesulfonyl)homopiperazine Dihydrochloride

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 938440-64-3. Solubility: Water (200 mg/mL), DMSO (10 mg/mL). Addition of an aqueous solution of fasudil dihydrochloride into a buffer solution may significantly alter its solubility. Molecular Formula: C14H17N3O2S2HCl. Molecular Weight: 364.3.

 

 

A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 M), protein kinase G (Ki = 1.6 M), and myosin light chain kinase (Ki = 3.6 M). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 M). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.

 

Reference: 1. Watanabe, K. et al. Nature Biotech. 2007, 25, 681; 2. Swrd, K. et al. J. Physiol. 2000, 522, 33; 3. Takizawa, S. et al. Eur. J. Pharmacol. 1993, 250, 431; 4. Seto, M. et al. Eur. J. Pharmacol. 1991, 195, 267; 5. Shirotani, M. et al. J. Pharmacol. Exp. Ther. 1991, 259, 738; 6. Asano, T. et al. Eur. J. Pharmacol. 1990, 190, 365; 7. Sasaki, Y., and Sasaki, Y. Biochem. Biophys. Res. Commun. 1990, 171, 1182; 8. Asano, T. et al. Br. J. Pharmacol. 1989, 98, 1091.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. BML-EI233

 

Cayman Chemical

Cat. No. 10010559

 

Enzo Life Sciences 

Cat. No. BML-EI233

EMD

Cat. No. 371970

Tocris   

Cat. No. 0541

Sigma

Cat. No. H139

 

 

Caution Not fully tested. For research use only. Not for human use.

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