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Chemdea |
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Fasudil (HA 1077) Dihydrochloride
– ROCK Inhibitor |
Catalog # CD0160 |
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Price: 250 mg - $42; 500 mg - $69; 1 g - $129;
2 g - $234; 5 g - $545 Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx |
Availability: In stock |
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5-Isoquinolinesulfonyl)homopiperazine Dihydrochloride
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS.
Purity: 99% by HPLC. CAS# 938440-64-3. Solubility: Water (200
mg/mL), DMSO (10 mg/mL). Addition of an aqueous solution of fasudil dihydrochloride into a
buffer solution may significantly alter its solubility. Molecular Formula: C14H17N3O2S·2HCl. Molecular Weight: 364.3.
A cell-permeable, reversible, and ATP-competitive Ca2+
antagonist with anti-vasospastic properties.
Inhibits protein kinase A (Ki
= 1.6 µM), protein kinase G (Ki
= 1.6 µM), and myosin light chain kinase (Ki = 3.6 µM). Also reported to potently
inhibit Rho-associated kinase
(ROCK; IC50 = 10.7 µM). Prevents apoptosis and enhances the
survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
Reference: 1. Watanabe, K. et al. Nature Biotech. 2007, 25, 681; 2. Swärd, K. et al. J. Physiol. 2000, 522, 33; 3. Takizawa, S. et al. Eur. J. Pharmacol. 1993, 250, 431; 4. Seto, M. et al. Eur. J. Pharmacol. 1991, 195, 267; 5. Shirotani, M. et al. J. Pharmacol. Exp. Ther. 1991, 259, 738; 6. Asano, T. et al. Eur. J. Pharmacol. 1990, 190, 365; 7. Sasaki, Y., and Sasaki, Y. Biochem. Biophys. Res. Commun. 1990, 171, 1182; 8. Asano, T. et al. Br. J. Pharmacol. 1989, 98, 1091. |
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SAME PRODUCT AS: |
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Cat. No. BML-EI233 |
Cat. No. 10010559 |
Cat. No. BML-EI233 |
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Cat. No. 371970 |
Cat. No. 0541 |
Cat. No. H139 |
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CHEMDEA; |