PDGFR Tyrosine Kinase Inhibitor IV | RWJ 540973 | JNJ-10198409 | CAS 627518-40-5

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PDGFR Tyrosine Kinase Inhibitor IV (RWJ 540973, JNJ-10198409)	Catalog # CD0165
Price: 1 mg - $75; 5 mg - $250; 10 mg - $450; 25 mg - $850; 50 mg - $1450	Availability: In stock

3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 627518-40-5. Solubility: DMSO (10 mg/mL) and methanol (5 mg/mL). Molecular Formula: C₁₈H₁₆FN₃O₂. Molecular Weight: 325.3.

A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC₅₀ <33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC₅₀ = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC₅₀ = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC₅₀ = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC₅₀ = 3.1 µM, >10 µM, >10 µM, 45.8 µM and >100 µM, respectively).

References: Ho, C.Y., et al. J. Med. Chem. 2005, 48, 8163.

SAME PRODUCT AS:

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Cat. No. 521233

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Cat. No. J4649

Caution – Not fully tested. For research use only. Not for human use.

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