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PDGFR Tyrosine Kinase Inhibitor IV (RWJ 540973, JNJ-10198409)

Catalog # CD0165

Price:  1 mg - $75; 5 mg - $250; 10 mg - $450; 25 mg - $850; 50 mg - $1450

Availability:  In stock

 

 

3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine

 

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 627518-40-5. Solubility: DMSO (10 mg/mL) and methanol (5 mg/mL). Molecular Formula: C18H16FN3O2. Molecular Weight: 325.3.

 

 

A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 <33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 然, >10 然, >10 然, 45.8 然 and >100 然, respectively).

 

References: Ho, C.Y., et al. J. Med. Chem. 2005, 48, 8163.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical  

Cat. No. N/A

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. 521233

Tocris   

Cat. No. N/A

Sigma

Cat. No. J4649

 

 

Caution Not fully tested. For research use only. Not for human use.

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