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AS 604850 PI3Kg Inhibitor II

Catalog # CD0176

Price:  1 mg - $19; 5 mg - $69; 10 mg - $99; 25 mg - $199; 50 mg - $350; 100 mg - $499

Availability:  In stock

 

 

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione

 

Off white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥99% by HPLC. CAS# 648449-76-7. Solubility: DMSO (50 mg/mL) or ethanol (5 mg/mL). Mol. Formula: C11H5F2NO4S. Molecular Weight: 285.2.

 

 

A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kg (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Ka (IC50 = 4.5 M), PI 3-Kb and d (IC50 > 20 M), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit etter in vivo efficacy than LY294002 in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.

 

References: 1. Bilancio, A., et al. Blood 2006, 107, 642; 2. Camps, M., et al. Nat. Med. 2005, 11, 936.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. ALX-270-461

Cayman Chemical

Cat. No. 10010175

Enzo Life Sciences   

Cat. No. ALX-270-461

EMD

Cat. No. 528108

Tocris   

Cat. No. N/A

Sigma

Cat. No. A0231

 

 

 

 

 

Caution Not fully tested. For research use only. Not for human use.

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