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Chemdea |
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AS 604850 – PI3Kg Inhibitor II |
Catalog # CD0176 |
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Price: 1 mg - $19;
5 mg - $69; 10 mg - $99; 25 mg - $199; 50 mg - $350; 100 mg - $499 |
Availability: In stock |
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5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
Off white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥99% by HPLC. CAS# 648449-76-7. Solubility: DMSO (50 mg/mL) or ethanol (5 mg/mL). Mol. Formula: C11H5F2NO4S. Molecular Weight: 285.2.
A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kg (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Ka (IC50 = 4.5 µM), PI 3-Kb and d (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit etter in vivo efficacy than LY294002 in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
References: 1. Bilancio, A., et al. Blood 2006, 107, 642; 2. Camps, M., et al. Nat. Med. 2005, 11, 936. |
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SAME PRODUCT AS: |
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Cat. No. ALX-270-461 |
Cat. No. 10010175 |
Cat. No.
ALX-270-461 |
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Cat. No. 528108 |
Cat. No.
N/A |
Cat. No. A0231 |
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CHEMDEA; |