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Chemdea |
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TGX-221 – PI3Kb Inhibitor VI |
Catalog # CD0180 |
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Price: 1 mg - $35;
5 mg - $55; 10 mg - $95; 25 mg - $199; 50 mg - $350; 100 mg - $650; 1g -
inquire |
Availability: In stock |
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(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 98% by HPLC. CAS# 663619-89-4. Solubility: DMSO (10 mg/mL), ethanol (5 mg/mL). Molecular Formula: C21H24N4O2. Molecular Weight: 364.44.
A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kb (p110b IC50 = 0.005 µM, p110d IC50 = 0.1 µM, p110a IC50 = 5 µM, and p110b IC50 ≥3.5 µM) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110b-dependent responses both in cells in vitro and in animals in vivo.
References: 1. Chaussade, C., et al. Biochem. J. 2007, 404, 449; 2. Cosemans, J. M, et al. Blood 2006, 108, 3045; 3. Condliffe, A.M., et al. Blood 2005, 106, 1432; 4. Jackson, S.P., et al. Nat. Med. 2005, 11, 507.
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SAME PRODUCT AS: |
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Cat. No.
ALX-270-464 |
Cat. No. 10007349 |
Cat. No. ALX-270-464 |
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Cat. No. 528113 |
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N/A |
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CHEMDEA; |