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Chemdea |
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YM201636 – PIKfyve Inhibitor |
Catalog # CD0181 |
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Price: 1 mg - $35;
5 mg - $98; 10 mg - $175; 25 mg - $350; 50 mg - $650; 100 mg - $1200 |
Availability: In stock |
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6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 98% by HPLC. CAS# 371942-69-7. Solubility: DMSO (1 mg/mL) Enhanced solubility can be achieved by the addition of a small drop of TFA. Molecular Formula: C25H21N7O3. Molecular Weight: 467.5.
A cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110a (IC50 = 3.3 µM) and little activity against type IIg PtdInsP kinase even at concentrations as high as 10 µM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner.
Reference: Jefferies, H.B.J., et al. EMBO Reports 2008, 9, 164. |
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Cat. No. 524611 |
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CHEMDEA; |