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Chemdea |
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KU-55933 - ATM Kinase Inhibitor |
Catalog # CD0191 |
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Price: 1 mg - $39;
5 mg - $65; 10 mg - $95; 25 mg - $195; 50 mg - $295; 100 mg - $450; 200 mg -
$795; 1 g - $2950 |
Availability: In stock |
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2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 587871-26-9. Solubility: DMSO (4 mg/mL). Molecular Formula: C21H17NO3S2. Molecular Weight: 395.5.
A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
References: 1. Hickson, I. et al. Cancer Res. 2004, 64, 9152; 2. Eaton, J. S. et al. J. Clin. Invest. 2007, 117, 2723. 3. Crescenzi, E. et al. Clin. Cancer Res. 2008, 14, 1877. |
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Cat. No. 118500 |
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3544 |
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CHEMDEA; |