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Chemdea |
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NSC23766 Hydrochloride –
Rac1 Inhibitor |
Catalog # CD0192 |
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Price: 1 mg - $35; 5 mg - $75; 10 mg - $95; 25
mg - $199; 50 mg - $350; 100 mg - $590; 250 mg - $1250; 500 mg – inquire; 1 g
– inquire Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx |
Availability: In stock |
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N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS.
Purity: 99% by HPLC. CAS# 1177865-17-6;
CAS# 733767-34-5.
Solubility: water. Molecular Formula: C24H35N7*3HCl. Molecular Weight: 530.96.
A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.
Reference: 1. Desire, L., et al. J. Biol. Chem. 2005, 280, 37516; 2. Gao, Y., et al. Proc. Natl. Acad. Sci. USA 2004, 101, 7618. |
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SAME PRODUCT AS: |
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13196 |
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Cat. No. 553502 |
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2161 |
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CHEMDEA; |