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NSC23766 Hydrochloride Rac1 Inhibitor

Catalog # CD0192

Price:  1 mg - $35; 5 mg - $75; 10 mg - $95; 25 mg - $199; 50 mg - $350; 100 mg - $590; 250 mg - $1250; 500 mg inquire; 1 g inquire

Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx

Availability:  In stock

 

 

N6-​[2-​[[4-​(Diethylamino)-​1-​methylbutyl]amino]-​6-​methyl-​4-​pyrimidinyl]-​2-​methyl-​4,​6-​quinolinediamine trihydrochloride

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 1177865-17-6; CAS# 733767-34-5. Solubility: water. Molecular Formula: C24H35N7*3HCl. Molecular Weight: 530.96.

 

 

A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 M). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.

 

Reference: 1. Desire, L., et al. J. Biol. Chem. 2005, 280, 37516; 2. Gao, Y., et al. Proc. Natl. Acad. Sci. USA 2004, 101, 7618.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical

Cat. No. 13196

 

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. 553502

Tocris   

Cat. No. 2161

Sigma

Cat. No. N/A

 

 

Caution Not fully tested. For research use only. Not for human use.

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