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BEZ235 - NVP-BEZ235 – PI3Ka/g/d Inhibitor

Catalog # CD0195

Price:  5 mg - $29; 10 mg - $42; 25 mg - $59; 50 mg - $105; 100 mg - $169 (Price update September 2010)

Availability:  In stock

 

 

4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-a,a-dimethylbenzeneacetonitrile

 

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 915019-65-7. Solubility: DMSO (2 mg/mL). The hydrochloride form of NVP-BEZ235 (Cat # CD0196) has 10-fold higher solubility. Molecular Formula: C30H23N5O. Molecular Weight: 469.5.

 

 

 

Potent, orally active dual PI3K/mTOR inhibitor under clinical trials. Inhibits PI3 kinase (PI3K), with p110α IC50 = 4 nM, p110b IC50 =75 nM, p110d IC50 =7 nM, p110g IC50 =5 nM. BEZ235 showed high target specificity and demonstrated antiproliferative activity against tumor cell lines in animal models.

 

Reference: Maira, S. M et al. Mol. Cancer Ther. 2008, 7, 1851.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical

Cat. No. N/A

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. N/A

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

 

 

Caution – Not fully tested. For research use only. Not for human use.

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