|
|
Chemdea |
|
VEGFR Tyrosine Kinase Inhibitor II |
Catalog # CD0207 |
|
Price: 1 mg - $65;
5 mg - $99; 10 mg - $180; 25 mg - $395; 50 mg - $730; 100 mg - $1320 |
Availability: In stock |
|
N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 269390-69-4. Solubility: DMSO (5 mg/mL). Molecular Formula: C19H16ClN3O. Molecular Weight: 337.8.
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7.0 µM and 7.3 µM). Also displays antiangiogenic and antitumor properties. Does not inhibit the activities of CDK-1, c-Met, IGF-1R or PKA (IC50 > 10 µM).
References: Furet, P., et al. Bioorg. Med. Chem. Lett. 2003, 13, 2967. |
|
SAME PRODUCT AS: |
||
|
Cat. No.
N/A |
Cat. No. N/A |
Cat. No. N/A |
|
Cat. No. 676481 |
Cat. No.
N/A |
Cat. No. N/A |
|
CHEMDEA; |