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Chemdea |
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D942 – AMPK Activator |
Catalog # CD0219 |
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Price: 1 mg - $65;
5 mg - $99; 10 mg - $150; 25 mg - $295; 50 mg - $450; 100 mg - $850 |
Availability: In stock |
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5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic
acid
Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 849727-81-7. Solubility: DMSO (10 mg/mL). Molecular Formula: C22H21FO4. Molecular Weight: 368.4.
A cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
References: 1. Kosaka, T., et al. Anal. Chem. 2005, 77, 2050; 2. Baumann, P., et al. Exp. Cell Res. 2007, 313, 3592; 3. Roca, H., et al. Neoplasia. 2009, 11, 1309. |
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CHEMDEA; |