Our Ligands


Quote Larger Quantity


Akt Inhibitor X

Catalog # CD0225

Price:  1 mg - $95; 5 mg - $125; 10 mg - $225; 25 mg - $450: 50 mg - $750; 100 mg - $1350

Availability:  In stock



10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine hydrochloride


White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 98% by HPLC. CAS# 925681-41-0. Solubility: DMSO (60 mg/mL), water (1 mg/mL). Molecular Formula: C20H25ClN2O∙HCl. Molecular Weight: 381.4.



A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 μM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat # CD0223), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.


Reference: 1. Thimmaiah, K. N., et al. J. Biol. Chem. 2005, 280, 31924.; 2. Tsvetkov, A.S., et al. Proc. Natl. Acad. Sci. USA 2010, 107 (39), 16982.





Cat. No. N/A


Cayman Chemical  

Cat. No. N/A

Enzo Life Sciences 

Cat. No. N/A


Cat. No. 124020


Cat. No. N/A


Cat. No. N/A



Caution Not fully tested. For research use only. Not for human use.

CHEMDEA; 38 E Ridgewood Ave.; Suite 240; Ridgewood, NJ 07450; USA

tel: (201) 690-4091; fax: (201) 690-4092; e-mail:;  web: