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Chemdea |
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Akt Inhibitor X |
Catalog # CD0225 |
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Price: 1 mg - $95;
5 mg - $125; 10 mg - $225; 25 mg - $450: 50 mg - $750; 100 mg - $1350 |
Availability: In stock |
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10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine
hydrochloride
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 98% by HPLC. CAS# 925681-41-0. Solubility: DMSO (60 mg/mL), water (1 mg/mL). Molecular Formula: C20H25ClN2O∙HCl. Molecular Weight: 381.4.
A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 μM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat # CD0223), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.
Reference: 1. Thimmaiah, K. N., et al. J. Biol. Chem. 2005, 280, 31924.; 2. Tsvetkov, A.S., et
al. Proc. Natl. Acad. Sci. USA 2010, 107 (39), 16982. |
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Cat. No. 124020 |
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CHEMDEA; |