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AS-252424 – PI3Kg/CKII Inhibitor	Catalog # CD0228
Price:  1 mg - $25, 5 mg - $99, 10 mg - $155, 25 mg - $295	Availability:  In stock

5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥98% by HPLC. CAS# 900515-16-4. Solubility: DMSO (20 mg/mL). Molecular Formula: C₁₄H₈FNO₄S. Molecular Weight: 305.3.

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC₅₀= 30 nM, PI3Ka IC₅₀= 940 nM, PI3Kb IC₅₀= 20,000 nM and PI3Kd IC₅₀= 20,000 nM respectively.  AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC₅₀= 230 nM. In a mouse model of peritonitis, PI 3-Kg this compound inhibited neutrophil recruitment 35% at a dose of 10 mg/kg.

Reference: Pomel, V., et al. J. Med. Chem. 2006, 49, 3857

SAME PRODUCT AS:
Axxora Cat. No. ALX-270-465	Cayman Chemical Cat. No. 10009052	Enzo Life Sciences  Cat. No. ALX-270-465
EMD Cat. No. 528112	Tocris Cat. No. 3671	Sigma Cat. No. A8981

Caution – Not fully tested. For research use only. Not for human use.

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