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AS-252424 PI3Kg/CKII Inhibitor

Catalog # CD0228

Price:  1 mg - $25, 5 mg - $99, 10 mg - $155, 25 mg - $295

Availability:  In stock

 

 

5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

 

Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥98% by HPLC. CAS# 900515-16-4. Solubility: DMSO (20 mg/mL). Molecular Formula: C14H8FNO4S. Molecular Weight: 305.3.

 

 

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC50= 30 nM, PI3Ka IC50= 940 nM, PI3Kb IC50= 20,000 nM and PI3Kd IC50= 20,000 nM respectively.  AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50= 230 nM. In a mouse model of peritonitis, PI 3-Kg this compound inhibited neutrophil recruitment 35% at a dose of 10 mg/kg.

 

Reference: Pomel, V., et al. J. Med. Chem. 2006, 49, 3857

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. ALX-270-465

 

Cayman Chemical  

Cat. No. 10009052

Enzo Life Sciences 

Cat. No. ALX-270-465

EMD

Cat. No. 528112

Tocris   

Cat. No. 3671

Sigma

Cat. No. A8981

 

 

 

 

 

Caution Not fully tested. For research use only. Not for human use.

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