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ZSTK474 PI3K a/b/g/d Inhibitor

Catalog # CD0237

Price: 10 mg - $25; 25 mg - $37; 50 mg - $49; 100 mg - $86; 250 mg - $185, 1 g - $352

Availability:  Inquire

 

 

2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 475110-96-4. Solubility: DMSO (20 mg/mL). Molecular Formula: C19H21F2N7O2. Molecular Weight: 417.4.

 

 

Cell permeable, reversible, potent and specific inhibitor of phosphoinositide 3-kinase (PI(3)K p110a IC50=6.7 nM, p110b IC50=10.4 nM, p110g IC50=11.7 nM and p110δ Ki=1.8 nM). Blocks cellular PI(3)K/Akt (PKB) signalling in vitro and inhibits Akt(PKB)-dependent tumor growth in mice in vivo without significant toxic effect. More effective than LY 294,002 in vitro and as in vivo.

 

Refeferences: 1. Yaguchi, S. et al.; Proc. Am. Assoc. Cancer Res. 2005, 46, 1691; 2. Yaguchi, S. et al.; J. Natl. Cancer Inst. 2006, 98, 545; 3. Kong, D. and Yamori, T. Cancer Sci. 2007, 98, 1638.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical  

Cat. No. N/A

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. N/A

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

 

 

Note: Not available in some countries; not available to some institutions; not available for some uses.

 

Caution Not fully tested. For research use only. Not for human use.

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