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Chemdea |
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AS041164 – PI3Kg Inhibitor VII |
Catalog # CD0240 |
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Price: 1 mg - $15;
5 mg - $25; 10 mg - $50; 25 mg - $90; 50 mg - $180; 100 mg - $250 |
Availability: In stock |
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5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 6318-41-8. Solubility: DMSO (40 mg/mL). Molecular Formula: C11H7NO4S. Molecular Weight: 249.2.
A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI3-K inhibitor (g isoform IC50 = 0.07 µM, (a isoform IC50 = 0.24 µM, (b isoform IC50 = 1.45 µM, and (d isoform IC50 = 1.70 µM) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 µM). Exhibits similar pharmacokinetics as LY 294002 via oral administration, but is 3-times as potent (ED50 = 27.35 mg/kg, p.o.) in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o)
Reference: Ferrandi, C., et al. J. Pharmacol. Exp. Ther. 2007, 322, 923. |
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SAME PRODUCT AS: |
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Cat. No. BML-E390 |
Cat. No. 13622 |
Cat. No. BML-E390 |
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Cat. No. 528114 |
Cat. No. N/A |
Cat. No. N/A |
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CHEMDEA; |