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Chemdea |
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GDC-0941 – PI3Ka/d Inhibitor |
Catalog # CD0245 |
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Price: 1 mg - $10;
5 mg - $15; 10 mg - $19; 25 mg - $49; 50 mg - $88; 100 mg - $168; 200 mg -
$314; 500 mg - $765; 1 g - $1294 |
Availability: In stock |
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2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 957054-30-7. Solubility: DMSO (66 mg/mL). Note: the bismesylate form marketed by other vendors is poorly soluble in organic solvents and water. Molecular Formula: C23H27N7O3S2. Molecular Weight: 513.6.
Potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) under clinical trials, with p110α IC50 = 3 nM, p110b IC50 =33 nM, p110d IC50 =3 nM, p110g IC50 =75 nM, DNA-PK IC50 =1230 nM and mTOR IC50 =580 nM.
References: 1. Workman, P. et al. Mol Cancer Ther. 2009, 8, 1725; 2. Folkes, A. J. et al. J. Med. Chem. 2008, 51, 5522. |
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CHEMDEA; 38 E Ridgewood Ave.; Suite 240; Ridgewood, NJ 07450; USA |