Chemdea

 

Home

Our Ligands

Order

Quote Larger Quantity

  

AS-605240 PI3Kg Inhibitor

Catalog # CD0248

Price:  1 mg - $15; 5 mg - $30; 10 mg - $55; 25 mg - $130; 50 mg - $220; 100 mg - $350

Availability:  In stock

 

 

5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione

 

Pink to reddish solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥98% by HPLC. CAS# 648450-29-7. Solubility: DMSO (1 mg/mL). Molecular Formula: C12H7N3O2S. Molecular Weight: 257.3.

 

 

A cell-permeable thiazolidinedione compound that acts as a potent, selective, and ATP-competitive inhibitor of phosphatidylinositol 3-kinase g (PI 3-Kg) (Ki = 7.8 nM); p110g IC50 = 8 nM, p110a IC50 = 60 nM, p110b IC50 = 270 nM, p110d IC50 = 300 nM. Does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 M. Selectively blocks MCP-1, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human monocytic cell line THP-1 (IC50 = 181 nM). Also shown to exhibit in vivo efficacy in reducing neutrophil chemotaxis in murine peritonitis and arthritis models.

 

Reference: 1. Barber, D.F., et al. Nat. Med. 2005, 11, 933. 2. Camps, M., et al. Nat. Med. 2005, 11, 936.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. ALX-270-462

 

Cayman Chemical  

Cat. No. 10007707

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. 528106

Tocris   

Cat. No. 3578

Sigma

Cat. No. A0233

 

 

 

 

Caution Not fully tested. For research use only. Not for human use.

CHEMDEA; 38 E Ridgewood Ave.; Suite 240; Ridgewood, NJ 07450; USA

tel: (201) 690-4091; fax: (201) 690-4092; e-mail: contact@chemdea.com;  web: http://www.chemdea.com/