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Chemdea |
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AS-605240 – PI3Kg Inhibitor |
Catalog # CD0248 |
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Price: 1 mg - $15;
5 mg - $30; 10 mg - $55; 25 mg - $130; 50 mg - $220; 100 mg - $350 |
Availability: In stock |
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5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
Pink to reddish solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥98% by HPLC. CAS# 648450-29-7. Solubility: DMSO (1 mg/mL). Molecular Formula: C12H7N3O2S. Molecular Weight: 257.3.
A cell-permeable thiazolidinedione compound that acts as a potent, selective, and ATP-competitive inhibitor of phosphatidylinositol 3-kinase g (PI 3-Kg) (Ki = 7.8 nM); p110g IC50 = 8 nM, p110a IC50 = 60 nM, p110b IC50 = 270 nM, p110d IC50 = 300 nM. Does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 µM. Selectively blocks MCP-1, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg+/+ murine monocytes and in a human monocytic cell line THP-1 (IC50 = 181 nM). Also shown to exhibit in vivo efficacy in reducing neutrophil chemotaxis in murine peritonitis and arthritis models.
Reference: 1. Barber, D.F., et al. Nat. Med. 2005, 11, 933. 2. Camps, M., et al. Nat. Med. 2005, 11, 936. |
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SAME PRODUCT AS: |
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Cat. No.
ALX-270-462 |
Cat. No. 10007707 |
Cat. No. N/A |
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Cat. No. 528106 |
Cat. No. 3578 |
Cat. No. A0233 |
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