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WYE-354 mTOR Inhibitor

Catalog # CD0270

Price:  1 mg - $75; 5 mg - $95; 10 mg - $150; 25 mg - $350; 50 mg - $650; 100 mg - $950; 200 mg - $1750

Availability:  In stock

 

 

4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1piperidinecarboxylic acid methyl ester

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 1062169-56-5. Solubility: DMSO (50 mg/mL). Molecular Formula: C24H29N7O5. Molecular Weight: 495.5.

 

 

A cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP competitive inhibitor of mTOR (IC50 = 4 nM). Active in LNCap cellular assay (IC50 = 355 nM). Selective against PI3Ks (p110a IC50 = 1026 nM, p110b, p110g, p110d > 6000 nM). Selective against other PIKKs and other kinases. When injected into tumor-bearing nude mice, WYE-354 inhibited mTORC1 and mTORC2 and displayed robust antitumor activity in PTEN-null tumors.

 

Reference: 1. Yu, K., et al. Cancer Res. 2009, 69, 6232. 2. Zask, A. et al. J. Med. Chem. 2009, 52, 5013.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical  

Cat. No. N/A

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. 475986

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

Caution Not fully tested. For research use only. Not for human use.

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