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R-848 (Resiquimod, S 28463) TLR7 and TLR8 Ligand

Catalog # CD0271

Price:  1 mg - $35; 5 mg - $45; 10 mg - $85; 25 mg - $150; 50 mg - $250; 100 mg - $450; 250 mg - $950, 1 g - inquire

Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx

Availability:  In stock

 

 

4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. Endotoxin free. CAS# 144875-48-9. Solubility: DMSO. Molecular Formula: C17H22N4O2. Molecular Weight: 314.4.

 

 

 

R-848 is a selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Potent antitumor and antiviral compound. Stimulates antibody secretion, cytokine production, protection from apoptosis and CD80 upregulation.

 

Reference: 1. Volmer, C. et al.; J. Gen. Virol. 2011, 92, 534; 2. Grela, F. et al.; J. Immunol. 2011, 186, 284; 3. Pham Van, L. et al.; Eur. J. Immunol. 2011, 41, 1992; 4. Jensen, S. S. & Gad, M. J. Inflamm. 2010, 7, 37; 5. Butchar, J. P. et al. Clin. Cancer Res. 2010, 16, 2065; 6. Aumeunier, A. et al. PLOS ONE 2010, 5, e11484; 7. Xirakia, C. et al. Am. J. Respir. Crit. Care Med. 2010, 181, 1207; 8. Peters, A. L. et al. Blood 2008, 112, 1863; 9. McCluskie, M. J. et al. Antiviral Res. 2006, 69, 77; 10. Caron, G. et al. J. Immunol. 2005, 175, 1551; 11. Weeratna, R. D. et al. Vaccine 2005, 23, 5263; 12. Wu, J. et al. Antiviral Res. 2004, 64, 79; 13. Jurk, M. et al. Nat. Immunol. 2002, 3, 499; 14. Hemmi, H. et al. Nat. Immunol. 2002, 3, 196; 15. Bishop, G. A. et al. Cell. Immunol. 2001, 208, 9.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. ALX-420-038

 

Cayman Chemical

Cat. No. N/A

 

Enzo Life Sciences 

Cat. No. ALX-420-038

EMD

Cat. No. N/A

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

Caution Not fully tested. For research use only. Not for human use.

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