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Ku-0063794 mTOR Inhibitor

Catalog # CD0274

Price:  1 mg - $29; 5 mg - $43; 10 mg - $78; 25 mg - $171; 50 mg - $243; 100 mg - $464; 200 mg - $844, 1 g - $2979 

Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx

Availability:  In stock





Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 938440-64-3. Solubility: DMSO (15 mg/mL). Molecular Formula: C25H31N5O4. Molecular Weight: 465.5.



Ku-0063794  inhibits both mTORC1 and mTORC2 with an IC50 of 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks at 1000-fold higher concentrations. Ku-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase). Ku-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. Ku-0063794 is a prototype of mTOR inhibitor AZD8055 currently in Phase I/II trial in Advance Solid Tumors, Lymphoma and Endometrial Carcinoma.


Reference: GarcíaMartínez, J. M. et al. Biochem J. 2009, 421, 29.





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Enzo Life Sciences 

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Caution – Not fully tested. For research use only. Not for human use.

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