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Wortmannin (KY 12420)

Catalog # CD0277

Price: 1 mg - $15; 5 mg - $25; 10 mg - $31; 25 mg - $68; 50 mg - $128;

100 mg - $237; 300 mg - $587

Availability:  In stock

 

 

Wortmannin

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 19545-26-7. Solubility: DMSO (25 mg/mL), MeOH (5 mg/mL). Molecular Formula: C23H24O8. Molecular Weight: 428.4. Isolated from Talaromyces wortmannin KY 12420.

 

 

A cell-permeable, fungal metabolite that acts as a potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase in purified preparations and cytosolic fractions (IC50 = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Preincubation of fibroblasts with Wortmannin abolishes PDGF-mediated Ins(3,4,5)P3 formation (IC50 = 5 nM). Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (200 - 300 nM). Also inhibits other kinases such as myosin light chain kinase (IC50 = 200 nM) and PI 4-kinase at concentrations higher than that required for inhibition of PI 3-kinase. Also blocks phospholipase D.

 

References: 1. Arcaro, A et al, Biochem. J. 1993, 296, 297; 2. Powis, G. et al, Cancer Res. 1994, 54, 2419; 3. Schultz et al, Anticancer Res. 1995, 15, 1135; 4. Liu, Y. et al, Chem. Biol. 2005, 12, 99.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. BML-ST415

 

Cayman Chemical  

Cat. No. 10010591

Enzo Life Sciences 

Cat. No. BML-ST415

EMD

Cat. No. 681675

Tocris   

Cat. No. 1232

Sigma

Cat. No. W1628

 

 

Caution Not fully tested. For research use only. Not for human use.

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