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Chemdea |
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Wortmannin (KY 12420) |
Catalog # CD0277 |
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Price: 1 mg - $15; 5
mg - $25; 10 mg - $31; 25 mg - $68; 50 mg - $128; 100 mg - $237; 300 mg - $587
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Availability: In stock |
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Wortmannin
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 19545-26-7. Solubility: DMSO (25 mg/mL), MeOH (5 mg/mL). Molecular Formula: C23H24O8. Molecular Weight: 428.4. Isolated from Talaromyces wortmannin KY 12420.
A cell-permeable,
fungal metabolite that acts as a potent, selective, and irreversible
inhibitor of phosphatidylinositol 3-kinase in purified preparations and
cytosolic fractions (IC50 = 5 nM). Blocks the catalytic activity
of PI 3-kinase without affecting the upstream signaling events. Preincubation
of fibroblasts with Wortmannin abolishes PDGF-mediated Ins(3,4,5)P3
formation (IC50 = 5 nM). Also blocks the metabolic effects of
insulin in isolated rat adipocytes without affecting the insulin receptor
tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet
activating factor in guinea pig neutrophils (200 - 300 nM). Also inhibits
other kinases such as myosin light chain kinase (IC50 = 200 nM)
and PI 4-kinase at concentrations higher than that required for inhibition of
PI 3-kinase. Also blocks phospholipase D. References: 1. Arcaro, A et al, Biochem. J. 1993, 296, 297; 2. Powis, G. et al, Cancer Res. 1994, 54, 2419; 3. Schultz et al, Anticancer Res. 1995, 15, 1135; 4. Liu, Y. et al, Chem. Biol. 2005, 12, 99. |
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SAME PRODUCT AS: |
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Cat. No. BML-ST415 |
Cat. No. 10010591 |
Cat. No. BML-ST415 |
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Cat. No.
681675 |
Cat. No.
1232 |
Cat. No.
W1628 |
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CHEMDEA; |