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Chemdea |
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IC87114 - PI3Kδ
Inhibitor |
Catalog # CD0283 |
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Price: 1 mg - $35;
5 mg - $55; 10 mg - $95; 25 mg - $195; 50 mg - $350; 100 mg - $650; 200 mg -
$1250; 1 g - inquire |
Availability: In stock |
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2-[6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 97% by HPLC. CAS# 371242-69-2. Solubility: DMSO (5 mg/mL). Molecular Formula: C22H19N7O. Molecular Weight: 397.44.
A cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
References: 1. Billottet, C., et al. Cancer Res. 2009, 69, 1027; 2. Ali, K., et al. J. Immunol. 2008, 180, 2538; 3. Lee, K. S. et al. The FASEB Journal 2006, 20, 455. |
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CHEMDEA; |