PP1 Src Inhibitor | CAS 172889-26-8

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PP1 – Src Inhibitor	Catalog # CD0334
Price: 1 mg - $50; 5 mg - $75; 10 mg - $120; 25 mg - $280; 50 mg - $490; 100 mg - $890	Availability: In stock

4-Amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo-d-3,4-pyrimidine

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 172889-26-8. Solubility: DMSO (25 mg/mL). Molecular Formula: C₁₆H₁₉N₅. Molecular Weight: 281.36.

A cell-permeable pyrazolopyrimidine compound that is shown to inhibit Src family tyrosine kinases Lck, Fyn, Hck, and Src (IC₅₀ = 5, 6, 20, and 170 nM, respectively), as well as non-Src family kinases such as CSK, RIP2, and CK1δ (IC₅₀ = 640 nM, 26 nM, 170 nM, respectively), in in vitro kinase assays. At 1 µM, in vitro kinase activity is reduced by more than 57% for p38α, p38β, CK1δ, CSK, RIP2, and GAK, while exhibiting much lower activity against more than 60 other kinases. Kinetic studies employing Src and [poly Glu-Tyr 4:1] indicate that the inhibition is mixed competitive with respect to the substrate and non-competitive with respect to ATP. PP1 also demonstrates anti-growth properties in several B lymphoma cultures of human and murine origins (IC₅₀ = 2.5 to 8.0 µM) and pediatric brain tumor cells (IC₅₀ = 1.1 to 9.7 µM).