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LY 294002 PI3K Inhibitor

Catalog # CD0342

Price: 5 mg - $15; 10 mg - $20; 25 mg - $24; 50 mg - $45; 100 mg - $85; 200 mg - $150; 300 mg - $212; 1 g - $654

Availability:  In stock

 

 

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

 

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity > 99% by HPLC. CAS# 154447-36-6. Solubility: DMSO (20 mg/mL) and ethanol (15 mg/mL). Molecular Formula: C19H17NO3. Molecular Weight: 307.4.

 

 

A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 M) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 M. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis.

 

References: 1. Lee, J., et al. 2009. Cell Stem Cell 2009, 5, 76; 2. Baumann, P., and West, S.C. Proc. Natl. Acad. Sci. USA 1998, 95, 14066; 3. Cardone, M.H., et al. Science 1998, 282, 1318; 4. Vlahos, C.J., et al. J. Immunol. 1995, 154, 2413; 5. Yano, H., et al. Biochem. J. 1995, 312, 145; 6. Vlahos, C.J., et al. J. Biol. Chem. 1994, 269, 5241.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. BML-ST420

 

Cayman Chemical  

Cat. No. 70920

 

Enzo Life Sciences 

Cat. No. BML-ST420

EMD

Cat. No. 440202

Tocris   

Cat. No. 1130 (salt form)

Sigma

Cat. No. L9908 (salt form)

 

 

Caution Not fully tested. For research use only. Not for human use.

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