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Chemdea |
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LY 294002 – PI3K
Inhibitor |
Catalog # CD0342 |
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Price: 5 mg - $15;
10 mg - $20; 25 mg - $24; 50 mg - $45; 100 mg - $85; 200 mg - $150; 300 mg -
$212; 1 g - $654 |
Availability: In stock |
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2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity > 99% by HPLC. CAS# 154447-36-6. Solubility: DMSO (20 mg/mL) and ethanol (15 mg/mL). Molecular Formula: C19H17NO3. Molecular Weight: 307.4.
A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis.
References: 1. Lee, J., et al. 2009. Cell Stem Cell 2009, 5, 76; 2. Baumann, P., and West, S.C. Proc. Natl. Acad. Sci. USA 1998, 95, 14066; 3. Cardone, M.H., et al. Science 1998, 282, 1318; 4. Vlahos, C.J., et al. J. Immunol. 1995, 154, 2413; 5. Yano, H., et al. Biochem. J. 1995, 312, 145; 6. Vlahos, C.J., et al. J. Biol. Chem. 1994, 269, 5241. |
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SAME PRODUCT AS: |
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Cat. No.
BML-ST420 |
Cat. No. 70920 |
Cat. No. BML-ST420 |
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Cat. No. 440202 |
Cat. No.
1130 (salt form) |
Cat. No. L9908 (salt form) |
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CHEMDEA; |