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PI-103 PI3K, mTOR and DNA-PK Inhibitor

Catalog # CD0113

Price:  1 mg - $19; 5 mg - $50; 10 mg - $75; 25 mg - $135; 50 mg - $260; 100 mg - $499; 250 mg - $950; 1 g - inquire

Availability:  In stock

 

 

3-(4-(4-Morpholinyl)pyrido[3,2:4,5]furo[3,2-d]pyrimidin-2-yl)phenol

 

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 371935-74-9. Solubility: DMSO (5 mg/mL; slight warming might be required to complete solubilization). A 6-fold more soluble hydrochloride salt of PI-103 is also available (Cat# CD0205). Molecular Formula: C19H16N4O3. Molecular Weight: 348.4.

 

 

A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50; DNA-PK = 2 nM, p110a = 8 nM , p110b = 88 nM, p110d = 48 nM, p110g = 150 nM, PI3-KC2b = 26 nM, mTORC1 = 20 nM, and mTORC2 = 83 nM). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 M. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.

 

References: 1. Raynaud, F.I., et al. Cancer Res. 2007, 67, 5840; 2. Fan, Q.W., et al. Cancer Cell 2006, 9, 341; 3. Knight, Z. A., et al. Cell 2006, 125, 733.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. ALX-270-460 

Cayman Chemical  

Cat. No. 10009209

Enzo Life Sciences 

Cat. No. ALX-270-460 

EMD

Cat. No. 528100

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

 

Caution Not fully tested. For research use only. Not for human use.

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