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Chemdea |
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PI-103 – PI3K, mTOR and DNA-PK Inhibitor |
Catalog # CD0113 |
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Price: 1 mg - $19;
5 mg - $50; 10 mg - $75; 25 mg - $135; 50 mg - $260; 100 mg - $499; 250 mg -
$950; 1 g - inquire |
Availability: In stock |
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3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 371935-74-9. Solubility: DMSO (5 mg/mL; slight warming might be required to complete solubilization). A 6-fold more soluble hydrochloride salt of PI-103 is also available (Cat# CD0205). Molecular Formula: C19H16N4O3. Molecular Weight: 348.4.
A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50; DNA-PK = 2 nM, p110a = 8 nM , p110b = 88 nM, p110d = 48 nM, p110g = 150 nM, PI3-KC2b = 26 nM, mTORC1 = 20 nM, and mTORC2 = 83 nM). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.
References: 1. Raynaud, F.I., et al. Cancer Res. 2007, 67, 5840; 2. Fan, Q.W., et al. Cancer Cell 2006, 9, 341; 3. Knight, Z. A., et al. Cell 2006, 125, 733. |
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SAME PRODUCT AS: |
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Cat. No. ALX-270-460 |
Cat. No. 10009209 |
Cat. No. ALX-270-460 |
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Cat. No. 528100 |
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CHEMDEA; 38 E Ridgewood Ave.; Suite 240; Ridgewood, NJ 07450; USA |