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PI-103 Hydrochloride PI3K, mTOR and DNA-PK Inhibitor

Catalog # CD0205

Price:  1 mg - $19; 5 mg - $70; 10 mg - $99; 25 mg - $199; 50 mg - $350; 100 mg - $499

Availability:  In stock

 

 

3-(4-(4-Morpholinyl)pyrido[3,2:4,5]furo[3,2-d]pyrimidin-2-yl)phenol Hydrochloride

 

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 371935-79-4. Solubility: DMSO (30 mg/mL). This hydrochloride salt form is 6-fold more soluble than the corresponding free base (Cat# CD0113). Molecular Formula: C19H16N4O3*HCl. Molecular Weight: 384.8.

 

A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50; DNA-PK = 2 nM, p110a = 8 nM , p110b = 88 nM, p110d = 48nM, p110g = 150 nM, PI3-KC2b = 26 nM, mTORC1 = 20 nM, and mTORC2 = 83 nM). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 M. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.

 

References: 1. Raynaud, F.I., et al. Cancer Res. 2007, 67, 5840; 2. Fan, Q.W., et al. Cancer Cell 2006, 9, 341; 3. Knight, Z.A., et al. Cell 2006, 125, 733.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical  

Cat. No. N/A

Enzo Life Sciences   

Cat. No. N/A

EMD

Cat. No. N/A

Tocris   

Cat. No. 2930

Sigma

Cat. No. N/A

 

 

Caution Not fully tested. For research use only. Not for human use.

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