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Dorsomorphin (Compound C) AMPK Inhibitor

Catalog # CD0185

Price:  1 mg - $35; 5 mg - $50; 10 mg - $75; 25 mg - $140; 50 mg - $250; 100 mg - $450; 250 mg - $750

Availability:  In stock

 

 

6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine

 

Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 866405-64-3. Solubility: DMSO (4 mg/mL). The dihydrochloride form of this product (Cat# CD0339) has improved aqueous solubility. Molecular Formula: C24H25N5O. Molecular Weight: 399.5.

 

 

A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 M ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCq, PKA, or JAK3. Blocks celluar activities induced by AICAr or Metformin. Induces weight loss by attenuating AMPK-mediated food intake in mice.

 

References: 1. Yu, P.B., et al. Nat. Chem. Biol 2008, 4, 33; 2. Kim, E.K., et al. J. Biol. Chem. 2004, 279, 19970; 3. Inoki, K., et al. Cell 2003, 115, 577; 4. Fryer, L.G., FEBS Lett. 2002, 531, 189; 5. Zhou, G., et al. J. Clin. Invest. 2001, 108, 1167.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. BML-EI369

 

Cayman Chemical

Cat. No. N/A

Enzo Life Sciences 

Cat. No. BML-275

EMD

Cat. No. 171260

Tocris   

Cat. No. N/A

Sigma

Cat. No. P5499

 

 

 

Caution Not fully tested. For research use only. Not for human use.

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