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Chemdea |
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Dorsomorphin (Compound C) Dihydrochloride
– AMPK Inhibitor |
Catalog # CD0339 |
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Price: 1 mg - $35; 5 mg - $50; 10 mg - $75; 25 mg - $140; 50 mg - $250; 100 mg - $450; 250 mg - $750 |
Availability: In stock |
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6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine dihydrochloride
Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 1219168-18-9. Solubility: DMSO (5 mg/mL) and water (50 mg/mL). Dorsomorphin dihydrochloride has improved water solubility as compared to the free base form (Cat# CD0185). Molecular Formula: C24H25N5O*HCl. Molecular Weight: 472.41.
A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCq, PKA, or JAK3. Blocks celluar activities induced by AICAr or Metformin. Induces weight loss by attenuating AMPK-mediated food intake in mice.
References: 1. Yu, P.B., et al. Nat. Chem. Biol 2008, 4, 33; 2. Kim, E.K., et al. J. Biol. Chem. 2004, 279, 19970; 3. Inoki, K., et al. Cell 2003, 115, 577; 4. Fryer, L.G., FEBS Lett. 2002, 531, 189; 5. Zhou, G., et al. J. Clin. Invest. 2001, 108, 1167. |
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