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Compound 15e – PI3Ka Inhibitor

Catalog # CD0189

Price:  1 mg - $30; 5 mg - $99; 10 mg - $180; 25 mg - $330; 50 mg – $450

Availability:  In stock

 

 

3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥99% by HPLC. CAS# 371943-05-4. Solubility: DMSO (25 mg/mL) and DMF (30 mg/mL). The hydrochloride salt of this compound (Cat# CD0261) is 2-fold less soluble. Molecular Formula: C16H15N3O2S. Molecular Weight: 313.4.

 

A cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-Ks (p110a IC50 = 2 nM, p110b IC50 = 16 nM, p110g IC50 = 660 nM, and PI 3-K C2b IC50 = 220 nM) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥3.4 µM for Cdk2/E, KDR, PKA, and PKCa). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50 <3 µM) in A375 melanoma cells.

 

Reference: Hayakawa, M., et al. Bioorg. Med. Chem. 2006, 14, 6847.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. ALX-270-455

Cayman Chemical  

Cat. No. 10010177

Enzo Life Sciences 

Cat. No. ALX-270-455

EMD

Cat. No. N/A

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

 

 

 

Caution – Not fully tested. For research use only. Not for human use.

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