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Chemdea |
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Compound 15e Dihydrochloride – PI3Ka Inhibitor |
Catalog # CD0261 |
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Price: 1 mg - $30; 5 mg - $99; 10 mg - $180; 50 mg – $450 |
Availability: In stock |
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3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol dihydrochloride
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥99% by HPLC. CAS# 371942-59-5. Solubility: DMSO (10 mg/mL). The free base form of this compound (Cat# CD0189) is 2.5-fold more soluble. Molecular Formula: C16H15N3O2S*2HCl. Molecular Weight: 386.3.
A cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-Ks (p110a IC50 = 2 nM, p110b IC50 = 16 nM, p110g IC50 = 660 nM, and PI 3-K C2b IC50 = 220 nM) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥3.4 µM for Cdk2/E, KDR, PKA, and PKCa). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50 <3 µM) in A375 melanoma cells.
Reference: Hayakawa, M., et al. Bioorg. Med. Chem. 2006, 14, 6847. |
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CHEMDEA; |