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Gardiquimod TLR7 Ligand

Catalog # CD0204

Price:  10 mg - $45; 25 mg - $95; 50 mg - $175; 100 mg - $325; 250 mg - $750, 1 g - inquire

Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx

Availability:  In stock

 

 

1-(4-Amino-2-ethylaminomethylimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. Endotoxin free. CAS# 1020412-43-4. Solubility: DMSO (>40 mg/mL), dioxane (7 mg/mL), methanol (>40 mg/mL). Molecular Formula: C17H23N5O. Molecular Weight: 313.4.

 

 

Selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-κB in HEK 293 cells expressing TLR7. At high concentrations (3g/ml) slightly activates TLR8. More active than Imiquimod (Cat# CD0115).

 

Reference: 1. Velasquez, L. S. et al. Clin Vaccine Immunol. 2010, 17, 1850; 2. Du, J. et al. Vaccine. et al. 2010, 28, 6273; 3. Ma, F. et al. Cell Mol Immunol. 2010, 7, 381; 4. Gill, M. A. et al. J Immunol. 2010, 184, 5999; 5. Ma, Y. et al. Immunology. 2010, 130, 374; 6. Forward, N. A. et al. J Leukoc Biol. 2010, 87, 117; 7. Baldwin, S. L. et al. Vaccine. 2009, 27, 3063; 8. Zhu, J. et al. Mol Immunol. 2009, 46, 978; 9. Parker, L. C. et al. J Immunol. 2008, 181, 5606; 10. Kalali, B. N. et al. J Immunol. 2008, 181, 2694; 11. Zhu, J. et al. Mol Immunol. 2008, 45, 3238.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. ALX-420-040

 

Cayman Chemical

Cat. No. N/A

 

Enzo Life Sciences 

Cat. No. ALX-420-040

EMD

Cat. No. N/A

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

Caution Not fully tested. For research use only. Not for human use.

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