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Rho Kinase Inhibitor III (Rockout) ROCK Inhibitor

Catalog # CD0222

Price:  5 mg - $35; 10 mg - $55; 25 mg - $125; 50 mg - $195; 100 mg - $350; 200 mg - inquire

Shipping and handling fee: Within USA - $15; International - $39; Delivery by FedEx

Availability:  In stock

 

 

3-(4-Pyridyl)-1H-indole

 

Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 7272-84-6. Solubility: DMSO (25 mg/mL). Molecular Formula: C13H10N2. Molecular Weight: 194.2.

 

A cell-permeable, selective, reversible, and ATP-competitive inhibitor of Rho kinase activity (IC50 = 25 M). Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat# CD0141; IC50 ~5 M), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 ~12 M in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 M.

 

Reference: Yarrow, J.C. et al. Chem. Biol. 2005, 12, 385.

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical

Cat. No. N/A

 

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. 555553

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

Caution Not fully tested. For research use only. Not for human use.

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