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WYE-23 sub-nanomolar selective mTOR Inhibitor

Catalog # CD0275

Price:  1 mg - $95; 5 mg - $199; 10 mg - $250; 25 mg - $450

Availability:  In stock

 

 

4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid methyl ester

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 1062169-46-3. Solubility: DMSO (11 mg/mL). Molecular Formula: C26H32N8O4. Molecular Weight: 520.6.

 

 

Novel potent and selective mTOR inhibitor. Inhibits mTOR kinase with IC50 = 0.45 nM and PI3 kinase (PI3K), with p110α IC50 = 661 nM. It shows improved cellular potency LNCap IC50 = 42 nM as compared to WYE-354 (Cat # CD0270). WYE-23 microsomal stability T1/2 was shown to be > 30 min.

 

References: 1. Zask, A. et al. J. Med. Chem. 2009, 52, 5013 (Compound 23). 2. Verheijen, J. C et al. J. Med. Chem. 2009, 52, 8010 (Compound 25c).

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical  

Cat. No. N/A

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. N/A

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

Caution Not fully tested. For research use only. Not for human use.

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