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Chemdea |
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WYE-23 – sub-nanomolar selective mTOR Inhibitor |
Catalog # CD0275 |
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Price: 1 mg - $95;
5 mg - $199; 10 mg - $250; 25 mg - $450 |
Availability: In stock |
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4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic
acid methyl ester
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 1062169-46-3. Solubility: DMSO (11 mg/mL). Molecular Formula: C26H32N8O4. Molecular Weight: 520.6.
Novel potent and selective mTOR inhibitor. Inhibits mTOR kinase with IC50 = 0.45 nM and PI3 kinase (PI3K), with p110α IC50 = 661 nM. It shows improved cellular potency LNCap IC50 = 42 nM as compared to WYE-354 (Cat # CD0270). WYE-23 microsomal stability T1/2 was shown to be > 30 min.
References: 1. Zask, A. et al. J. Med. Chem. 2009, 52, 5013 (Compound 23). 2. Verheijen, J. C et al. J. Med. Chem. 2009, 52, 8010 (Compound 25c). |
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CHEMDEA; 38 E Ridgewood Ave.; Suite 240; Ridgewood, NJ 07450; USA |