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Chemdea |
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PX-13-17OH – PI3K
Inhibitor |
Catalog # CD0305 |
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Price: 1 mg - $99;
5 mg - $150; 10 mg - $250; 25 mg - $550; 50 mg - $990; 100 mg - $1750 |
Availability: In stock |
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(1E,4S,4aR,5R,6aS,7S,9aR)-5-(Acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethylcyclopenta[5,6]na-phtho[1,2-c]pyran-2,10(1H,4H)-dione
Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 98% by HPLC. CAS# 884539-95-1. Solubility: DMSO (80 mg/mL), water (10 mg/mL). Molecular Formula: C29H42N2O8. Molecular Weight: 546.65.
PX-13-17OH is an irreversible, isoform non-specific Wortmannin analog which potently inhibits PI3Ka/b/g/d (IC50 = 6.4 nM, 13 nM, 8 nM and 11 nM respectively). PX-13-17OH does not appreciably inhibit mTOR (IC50 = 2.92 mM). In a kinase panel PX-13-17OH did not show significan inhibition of other kinases (IC50 > 10 mM). In a cellular assay PX-13-17OH inhibited the LNCap cell line (IC50 = 0.39 mM). In a nude mouse xenograft model (U87MG glioma) PX-13-17OH showed potent inhibition of tumor growth aldeardy at 1.25 mg/Kg in iv dosing. See also our product PX-866-17OH (Cat# CD0323) and 17-b-Hydroxywortmannin (Cat# CD0278) with similar activity.
References: Zask, A. et al. J. Med. Chem. 2008, 51, 1319. |
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CHEMDEA; |