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Chemdea |
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PX-866-17OH – PI3K
Inhibitor |
Catalog # CD0323 |
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Price: 1 mg - $99;
5 mg - $150; 10 mg - $250; 25 mg - $550; 50 mg - $990 |
Availability: Coming soon |
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(1E,4S,4aR,5R,6aS,7S,9aR)-
5-(Acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethylcyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione
Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity > 99% by HPLC. CAS# 1012327-63-7. Solubility: DMSO (50 mg/mL). Molecular Formula: C29H37NO8. Molecular Weight: 527.61.
PX-866-17OH is an irreversible, isoform non-specific Wortmannin analog which potently inhibits PI3Ka/b/g/d. PX-866-17OH is an 17-OH active metabolite of compound PX-866 (Cat# CD0279), that is a more potent PI-3K inhibitor than the parent compound and retains the same irreversible mechanism of action. See also our product PX-13-17OH (Cat# CD0305) and 17-b-Hydroxywortmannin (Cat# CD0278) with similar activity.
References: 1. http://www.oncothyreon.com/pipeline/small/px-866/overview.html; 2. Wipf, P., et al. Org. Biomol. Chem. 2004, 2, 1922. |
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CHEMDEA; |