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WYE-28 picomolar, selective mTOR Inhibitor

Catalog # CD0276

Price:  1 mg - $95; 5 mg - $199; 10 mg - $250; 25 mg - $450

Availability:  In stock

 

 

4-(6-{4-[3-(4-Hydroxymethyl-phenyl)-ureido]-phenyl}-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid methyl ester 

 

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: 99% by HPLC. CAS# 1062172-60-4. Solubility: DMSO (66 mg/mL). Molecular Formula: C30H34N8O5. Molecular Weight: 586.6.

 

 

Novel potent and selective mTOR inhibitor. Inhibits mTOR kinase with IC50 = 0.08 nM and PI3 kinase (PI3K), with p110α IC50 = 6 nM. It shows improved cellular potency LNCap IC50 < 1 nM as compared to WYE-354 (Cat # CD0270) and WYE-23 (Cat # CD0275).

 

References: Zask, A. et al. J. Med. Chem. 2009, 52, 5013 (Compound 28).

 

 

SAME PRODUCT AS:

Axxora 

Cat. No. N/A

 

Cayman Chemical  

Cat. No. N/A

Enzo Life Sciences 

Cat. No. N/A

EMD

Cat. No. N/A

Tocris   

Cat. No. N/A

Sigma

Cat. No. N/A

 

 

Caution Not fully tested. For research use only. Not for human use.

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